What clinical sign may take up to two weeks to resolve in cats exposed to metaldehyde?

The resolution of locomotor signs in cats exposed to metaldehyde may take up to two weeks due to the toxic effects of the substance on the central nervous system and muscle function. Metaldehyde, commonly found in certain pesticides and slug baits, affects neurotransmitter release and can lead to significant neurological disturbances.

Locomotor signs may manifest as ataxia, tremors, or difficulty in coordination, which are symptoms resulting from the impact of the toxin on motor pathways within the brain and spinal cord. These signs often persist due to the prolonged presence of the toxin in the body, which takes time for the cat’s system to metabolize and eliminate, leading to a longer recovery period compared to other immediate signs. Over time, as the cat detoxifies and the neurological function stabilizes, these locomotor issues will begin to improve.

In contrast, other signs such as mydriasis, hyperthermia, and seizures may resolve more quickly after the initial toxic exposure is managed since they are often more acute responses directly linked to the immediate neurotoxic effects of metaldehyde. This is why locomotor signs exhibit a longer duration before full recovery occurs in affected cats.