Which treatment is used for seizures associated with metalaldehyde toxicity?

In cases of metaldehyde toxicity, which is commonly associated with exposure to certain pesticide products like snail baits, seizures can be a significant clinical manifestation. Diazepam, a benzodiazepine, is typically used to control seizures due to its rapid onset of action and effectiveness in stabilizing neuromuscular activity. It works by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor, leading to increased inhibitory signaling in the brain.

This is crucial in managing seizure activity, as uncontrolled seizures can lead to further complications, including muscle damage or hypoxia. While other treatments may play a role in the overall management of metaldehyde toxicity, such as supportive care with IV fluids to maintain hydration or activated charcoal to decrease absorption if given shortly after exposure, they do not directly address the immediate need to control seizure activity. Methocarbamol, a muscle relaxant, may help with muscle spasms but it is typically not the first line treatment for seizures. Hence, diazepam stands out as the appropriate choice for seizure control in this specific context.